Download Chemotherapy Protocols and Infusion Sequence - Schedule Consideration in Cancer Treatment by Iago Dillion Lima Cavalcanti 2022 pdf Easily In Format For Free
There are several types of cancer treatment modalities, such as surgery, radiotherapy, chemotherapy, immunotherapy, and targeted therapy, in which the choice of the best therapeutic option will depend on several factors such as type of tumor, stage of cancer, age, and clinical conditions of the patients. Due to the complexity of cancer, the association of therapeutic modalities has been shown to be effective, such as the application of chemotherapy and/or radiotherapy after surgical procedures or the association of chemotherapy that enhance the effects of radiotherapy. The combination of anticancer drugs is also widely used, as they combine drugs that have different mechanisms of action, thereby enhancing the anticancer effect of the drugs. Although effective, the defnition of chemotherapy protocols must be well planned to ensure maximum treatment effcacy and minimal toxic effects. To defne the best combination between chemotherapeutics, some parameters must be taken into account. Attention should be paid to the mechanisms of action and pharmacokinetic profle of each drug, diluent solutions and drug stability when infused concomitantly, as well as the drug's toxicity profles, and the risks of dermatological toxicity due to vesicant, irritant, or not irritating characteristics.
These characteristics are important as they provide safety and effcacy to the treatment. Some studies highlight the importance of evaluating the order of infusion of the chemotherapy protocol due to possible pharmacodynamic and pharmacokinetic interactions, in which, depending on the infusion schedule, drugs may present antagonistic interactions with reduced therapeutic activity and increased toxicity, as well as depending on the order, they can present synergistic reactions with potentiation of therapeutic effects. Therefore, this book tries to bring out the importance of combined chemotherapy in the treatment of cancer, highlighting the main parameters that must be considered when defning the infusion schedule of the protocols. In addition, I address the main solid cancers, such as breast, gastrointestinal, genitourinary, gynecological, head and neck cancers, among others, bringing the main protocols indicated for each type of cancer, with scientifc studies of effcacy and data related to the infusion sequence. Protocols were based on data made available in scientifc articles, on the BC Cancer, University Hospital Southampton NHS Foundation websites, and in the vi book chemotherapy protocols 2017. The scarcity of articles that assess the infusion sequence of chemotherapy protocols reinforces the importance of this type of study to ensure maximum protocol effectiveness, as well as patient safety with the proposed therapy
